The pro-government vigilantes opened fire at the demonstrators late Wednesday and in the early hours of Thursday.
A Press TV correspondent also said intense shooting is going on around Tahrir Square on Thursday.
Preliminary reports say at least six protesters have been killed and over 1,500 injured over the past 24 hours.
A report by the United Nations says at least 300 people have so far been killed and thousands more injured during nationwide protests in troubled Egypt.
Main opposition figures have called for another mass rally on Friday, which they consider as President Hosni Mubarak’s day of departure